They also gave a look at the rather bloody main character.
PRODEUS IGG SOFTWARE
Yup, Bounding Box Software showed up at the Realms Deep shoot 'em ups showcase over the weekend to announce they'll be adding co-op. Similarly, the absence of secreted IgM also resulted in an accelerated development of IgG autoantibodies in normal mice. Retro-inspired shooter Prodeus has been blasting its way through early access since November and is about to get a helping hand. Compared with regular lpr mice, lpr mice that lack secreted IgM developed elevated levels of IgG autoantibodies to double-stranded DNA and histones and had more abundant deposits of immune complexes in the glomeruli they also suffered more severe glomerulonephritis and succumbed to the disease at an earlier age. Using mice that are unable to secrete IgM but are able to express surface IgM and IgD and to secrete other classes of immunoglobulins, we examined the effect of the absence of secreted IgM in the development of IgG autoantibodies and autoimmune disease in lupus-prone lymphoproliferative (lpr) mice. Although IgG autoantibodies often are pathogenic, the role of IgM autoantibodies in autoimmune disease is not clear. Individuals with systemic lupus erythematosus and rheumatoid arthritis are characterized by the presence of high levels of circulating IgM and IgG autoantibodies.
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